Cerebellar Ganglioglioma in Childhood: Histopathologic Implications for Management During Long-term Survival: A Case Report

URI http://repository.lib.tottori-u.ac.jp/Repository/metadata/5519
本文ファイル
DOI[info:doi/]
タイトル
Cerebellar Ganglioglioma in Childhood: Histopathologic Implications for Management During Long-term Survival: A Case Report
タイトル読み
タイトルその他
著者
著者 Ohno Koyo
著者読み
著者英語Author Ohno Koyo
所属Affiliation Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine
著者 Saito Yoshiaki
著者読み
著者英語Author Saito Yoshiaki
所属Affiliation Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine
著者 Tamasaki-Kondo Akiko
著者読み
著者英語Author Tamasaki-Kondo Akiko
所属Affiliation Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine
著者 Kambe Atsushi
著者読み
著者英語Author Kambe Atsushi
所属Affiliation Division of Neurosurgery, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine
著者 Horie Yasushi
著者読み
著者英語Author Horie Yasushi
所属Affiliation Division of Organ Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine
著者 Kato Shinsuke
著者読み
著者英語Author Kato Shinsuke
所属Affiliation Division of Neuropathology, Department of Brain and Neuroscience, Faculty of Medicine, School of Medicine, Tottori University Faculty of Medicine
著者 Maegaki Yoshihiro
著者読み
著者英語Author Maegaki Yoshihiro
所属Affiliation Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine
キーワード
childhood cerebellar tumor
Lhermitte–Duclos disease
mTOR
PTEN
NDC分類
4類 自然科学
内容

We report the case of a 19-year-old female with cerebellar ganglioglioma that was diagnosed at 4 years of age. Despite treatment with partial resection, radiation, and chemotherapy, residual tumor slowly expanded into the brainstem and upper cervical cord, resulting in nocturnal hypopnea, progressive tetraparesis, and feeding difficulty during 8–10 years of age. Initiation of temozolomide and bevacizumab was effective in preventing further expansion of the tumor, and the patient has been treated at home and in school with noninvasive positive pressure ventilation and gastrostomy. Histopathologic examination of the resected tumor tissue revealed phospho-S6-positive tumor cells of either neuronal or astroglial appearance. This suggests that a higher proportion of cells of glial lineage could be linked to the progression of cerebellar ganglioglioma in childhood. Possible treatment options with mammalian target of rapamycin inhibitors are discussed.

出版者
Tottori University Faculty of Medicine
資料タイプ
紀要論文
外部リンク
ISSN/ISBN
0513-5710
書誌ID
AA00892882
掲載誌・書籍タイトル
Yonago Acta Medica
60
4
開始ページ
255
終了ページ
259
発行日
2018-02-05
DOI
出版社版
著作権表記
掲載情報

Yonago Acta Medica. 2017, 60(4), 255-259

学部学科区分
医学研究科・医学部
本文言語
英語
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