ID 6263
File
Authors
Qian, Weibin Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Department of Lung Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Hasegawa, Junichi Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/National Hospital Organization,Yonago Medical Center KAKEN Search Researchers
Yang, Jie Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine
Endo, Yusuke Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital Tottori University Researchers
Miake, Junichiro Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Keywords
absorption
daijokito
portal vein sampling
ranitidine
rat model
NDC
Natural science
Abstract
【Background】 Daijokito (DJKT), a classical traditional Kampo and Chinese medicine, has been used to treat acute pancreatitis in China. In our previous study, DJKT was found to reduce the area under the plasma concentration-time curve (AUC) of ranitidine in humans.
Therefore, we established a novel rat model to examine the direct absorption of ranitidine after daijokito administration.
【Methods】 An in situ intestinal injection with portal vein sampling (IIPS) model was created to determine the rate of intestinal drug absorption. Rats were divided into two groups: the ranitidine group (R, n = 6) or the ranitidine and daijokito group (RD, n = 6). Blood was collected after intestinal injection of drugs. After the experiment, the concentrations of ranitidine were measured by LC/MS/MS analysis.
【Results】 The concentrations of ranitidine increased linearly with time in both groups. Compared with the R group, the concentrations of ranitidine in RD group significantly decreased throughout the experiment.
【Conclusion】 Co-administration of ranitidine with DJKT resulted in significant decreases in intestinal absorption in rats. The reduction of the systemic ranitidine concentration by co-administration of DJKT may be due, at least in part, to the inhibition of intestinal absorption
of ranitidine.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
13468049
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
61
Issue
4
Start Page
192
End Page
196
Published Date
2018
Text Version
Publisher
Citation
Yonago Acta Medica. 2018, 61(4), 192-196
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English