ID 6306
File
Authors
Yamamoto, Manabu Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Saito, Hiroaki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Uejima, Chihiro Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Tanio, Akimitsu Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Tada, Yoichiro Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Matsunaga, Tomoyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Sakamoto, Teruhisa Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Honjo, Soichiro Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Ashida, Keigo Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Fujiwara, Yoshiyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Keywords
carcinoembryonic antigen
colorectal cancer
Controlling Nutritional Status score
prognosis
Abstract
Background Nutritional status is strongly associated with prognosis in cancer patients. Controlling Nutritional Status (CONUT) score is a nutritional marker based on serum albumin, cholesterol, and total lymphocyte count. We investigated the prognostic significance of a combination of the tumor marker carcinoembryonic antigen (CEA) and CONUT score (T-CONUT) in colorectal cancer (CRC) patients.

Methods A total of 522 patients who underwent surgery for CRC at our hospital were retrospectively enrolled in this study.

Results Patients were divided into groups based on the results of receiver operating characteristic (ROC) curve analysis as follows: CONUThigh (CONUT score ≥ 3) and CONUTlow (CONUT score < 3), and CEAlow (< 5 ng/mL) and CEAhigh (≥ 5 ng/mL). The 5-year overall survival (OS) rates of patients in the CONUTlow and CONUThigh groups were 76.0% and 53.9%, respectively (P < 0.0001), and in the CEAlow and CEAhigh groups were 80.7% and 47.6%, respectively (P < 0.0001). Regarding T-CONUT, the 5-year OS rates of patients with CEAlow/CONUTlow, CEAlow/CONUThigh, CEAhigh/CONUTlow, and CEAhigh/CONUThigh were 84.7%, 69%, 55.3%, and 36.1%, respectively (P < 0.0001). Multivariate analysis identified T-CONUT score as an independent prognostic indicator in CRC patients.

Conclusion T-CONUT may be a useful tool for predicting prognosis in CRC patients.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN・ISBN
05135710
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
62
Issue
1
Start Page
124
End Page
130
Published Date
2019-03-28
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Yonago Acta Medica. 2019, 62(1), 124-130
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English