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Authors
Sako, Takanori
Keywords
alveolar volume
circadian rhythm
cosinor analysis
diurnal variation
lung diffusion capacity
Abstract
Diurnal variation in the lung diffusing function can influence the results of clinical evaluations. We investigated circadian rhythms from diurnal variations of the indices in the diffusing function of the lung. We measured the single breath lung diffusing capacity for carbon monoxide (DLCO) and alveolar volume (VA) in 13 healthy men, and also measured pulse rate at 7:00, 11:00, 15:00, 19:00 and 23:00. To identify the presence of a circadian rhythm from daily variations, data were analyzed by the group mean cosinor method. Significant circadian rhythms were apparent for DLCO/VA, VA and pulse rate. The acrophases for these parameters occurred at 20:15, 5:26 and 18:08, respectively. The double amplitude of DLCO/VA was statistically 4.72%. Our results suggest that diurnal variations in VA and pulse rate may contribute to the variation in DLCO/VA. Although DLCO/VA showed only a small change throughout the day, our findings suggest that the examination of DLCO/VA should be performed preferably at the same time of day in an individual.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
42
Issue
3
Start Page
189
End Page
192
Published Date
1999-11
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 1999, 42(3), 189-192
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English