File
Authors
Keywords
Alzheimer's disease
cerebral amyloid angiopathy
immunohistochemistry
perivascular plaque
senile plaque
Abstract
Immunohistochemical study of perivascular plaques (PPs) in 7 patients with Alzheimer’s disease (AD) and 4 with cerebral amyloid angiopathy (CAA)(CAA with dementia in 3 patients and CAA with massive cerebral hemorrhage in 1 patient) demonstrated that PPs were also a common form of amyloid β (Aβ) deposits, like SPs and CAAs, in both AD and CAA, and that they had similar immunostaining characteristics to mature senile plaques (SPs), manifesting as always positive for both Aβ42 and Aβ40 but predominant for Aβ42. In addition, PPs were always associated with AT8-positive degenerated neurites and GFAP-positive astrocytes and fibers. These findings suggest that PPs as mature plaques contribute to the development of dementia, especially in CAA with dementia which lack AD pathology. Moreover, semiquantitative analysis revealed no correlation between the number of PPs and that of SPs, but a good correlation between the number of PPs and that of CAAs, suggesting that there was a close relationship of the formation of PPs and the development of CAAs. PPs were also found around non-CAA arteries, although they were frequent around varying degrees of CAAs, suggesting that the initial Aβ42 deposits in PPs contribute to the development of CAAs.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
46
Issue
1
Start Page
9
End Page
16
Published Date
2003-03
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 2003, 46(1), 9-16
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English