File
Authors
Keywords
epididymis
spermatogenesis
testicular function
unilateral vasectomy
Abstract
We evaluated the effects of unilateral obstruction of the vas deferens on testicular endocrine and exocrine function in rats. The left vas deferens was ligated and divided in 1-week-old Wistar rats. Additional rats of the same age underwent a sham operation. Bilateral testicular weight and epididymal weight were compared between the vasectomized and sham-operated animals at 4, 8 and 12 weeks postoperation. Intratesticular versus intraabdominal temperature difference, epididymal caudal sperm content (ECSC), motility (ECSM) and in vitro fertilizing capacity (IVF) were compared between the vasectomized and sham-operated animals at 12 weeks postoperation. Serum testosterone response to human chorionic gonadotropin and bilateral testicular weight were significantly smaller in the vasectomized animals than in the sham-operated animals at 8 and 12 weeks postoperation. Bilateral ECSC, ECSM and IVF outcomes were significantly smaller in vasectomized rats than in sham-treated rats 12 weeks postoperatively. Bilateral intratesticular versus intraabdominal temperature differences were not significantly different between the vasectomized and control rats at 12 weeks postoperation. Unilateral obstruction of the vas deferens results in a bilateral defect in spermatogenesis and in the epididymal sperm maturation process.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
43
Issue
1
Start Page
1
End Page
9
Published Date
2000-03
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 2000, 43(1), 1-9
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English