File
Authors
Izawa, Hironori Graduate School of Engineering, Tottori University Researchers DB KAKEN
Nishio, Shoji Graduate School of Engineering, Tottori University
Maeda, Hiroyuki Graduate School of Engineering, Tottori University
Morita, Kohei Graduate School of Engineering, Tottori University
Ifuku, Shinsuke Graduate School of Engineering, Tottori University Researchers DB KAKEN
Morimoto, Minoru Graduate School of Engineering, Tottori University Researchers DB KAKEN
Saimoto, Hiroyuki Graduate School of Engineering, Tottori University Researchers DB KAKEN
Kadokawa, Jun-ichi Graduate School of Science and Engineering, Kagoshima University
Keywords
Xanthan gum
Hydroxyapatite
Alternate soaking process
Inorganic–organic composite hydrogel
Mineralization
Abstract
We previously reported a xanthan gum (Xan) hydrogel showing excellent mechanical properties. Mineralization of hydroxyapatite (Hap) upon the Xan hydrogel would provide a unique biomaterial applicable for bone tissue engineering. Here, we show the mineralization of Hap upon the Xan hydrogel by means of an alternate soaking process. Hap was gradually grown upon the Xan-matrix surface with increasing number of soaking cycles due to the ionic interactions between calcium cations and carboxyl groups. Interestingly, the mineralization induced a microstructure change in the gel-matrix from a layered structure to a porous structure. The mechanical properties of the resulting Hap–Xan composite hydrogels were further investigated by a tensile test, where the Hap–Xan composite hydrogel with an appropriate amount of Hap (Xan/Hap = 2.7) was capable of approximately 370% elongation.
Publisher
Elsevier Ltd.
Content Type
Journal Article
Link
ISSN・ISBN
01448617
NCID
AA11522761
Journal Title
Carbohydrate Polymers
Volume
102
Start Page
846
End Page
851
Published Date
2014-02-15
Publisher-DOI
Text Version
Author
Rights
Copyright © 2014 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
Citation
This research was published by Elsevier Ltd.: IZAWA, Hironori, et al. Mineralization of hydroxyapatite upon a unique xanthan gum hydrogel by an alternate soaking process. Carbohydrate polymers, 2014, 102: 846-851. https://doi.org/10.1016/j.carbpol.2013.10.080
Department
Faculty of Engineering/Graduate School of Engineering
Language
English