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Authors
Koizumi, Ryo Graduate School of Engineering, Tottori University
Azuma, Kazuo Department of Veterinary Clinical Medicine, Tottori University Tottori University Researchers KAKEN Search Researchers
Izawa, Hironori Graduate School of Engineering, Tottori University Tottori University Researchers KAKEN Search Researchers
Morimoto, Minoru Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University Tottori University Researchers KAKEN Search Researchers
Ochi, Kosuke Department of Veterinary Clinical Medicine, Tottori University
Tsuka, Takeshi Department of Veterinary Clinical Medicine, Tottori University Tottori University Researchers KAKEN Search Researchers
Imagawa, Tomohiro Department of Veterinary Clinical Medicine, Tottori University Tottori University Researchers KAKEN Search Researchers
Osaki, Tomohiro Department of Veterinary Clinical Medicine, Tottori University Tottori University Researchers KAKEN Search Researchers
Ito, Norihiko Department of Veterinary Clinical Medicine, Tottori University Tottori University Researchers KAKEN Search Researchers
Okamoto, Yoshiharu Department of Veterinary Clinical Medicine, Tottori University Tottori University Researchers KAKEN Search Researchers
Saimoto, Hiroyuki Graduate School of Engineering, Tottori University Tottori University Researchers KAKEN Search Researchers
Ifuku, Shinsuke Graduate School of Engineering, Tottori University Tottori University Researchers KAKEN Search Researchers
Keywords
surface deacetylated chitin nanofiber
chitosan
mucositis
5-fluorouracil
apoptosis
Abstract
This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.
Publisher
MDPI
Content Type
Journal Article
Link
ISSN・ISBN
14220067
NCID
AA12038549
Journal Title
International Journal of Molecular Sciences
Volume
18
Issue
2
Start Page
279
Published Date
2017-01-27
Publisher-DOI
Text Version
Publisher
Rights
© 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Citation
KOIZUMI, Ryo, et al. Oral administration of surface-deacetylated chitin nanofibers and chitosan inhibit 5-fluorouracil-induced intestinal mucositis in mice. International journal of molecular sciences, 2017, 18.2: 279. https://doi.org/10.3390/ijms18020279
Department
Faculty of Engineering/Graduate School of Engineering
Language
English