File
Authors
Osaki, Mitsuhiko Division of Pathological Biochemistry, Department of Biomedical Sciences, School of Life Science, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Okada, Futoshi Division of Pathological Biochemistry, Department of Biomedical Sciences, School of Life Science, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Keywords
cancer progression
exosome
extracellular vesicle
Abstract
Exosomes are a subset of extracellular vesicles and their size is approximately 100 nm in diameter. They are surrounded by a lipid bilayer membrane and secreted from almost all of cells. Exosomes are generated within the endocytic system as ILV (intraluminal membrane vesicle) and secreted during the fusion of MVB (multivesicular body) with the cell membrane. Recently it has been reported that exosomes modulate cell-cell communication contributing to the maintenance of tissue homeostasis by molecules including exosomes. Moreover, exosomes released from cancer cells are involved in cancer progression. Thus, data regarding the role of the exosomes in malignant cancer will lead to development of novel diagnostic and therapeutic methods.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN・ISBN
05135710
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
62
Issue
2
Start Page
182
End Page
190
Published Date
2019-06-20
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Mitsuhiko Osaki, Futoshi Okada, Exosomes and Their Role in Cancer Progression, Yonago Acta Medica, 2019, Volume 62, Issue 2, Pages 182-190
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English