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Authors
Ohno, Koyo Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine
Saito, Yoshiaki Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Tamasaki-Kondo, Akiko Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Kambe, Atsushi Division of Neurosurgery, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Horie, Yasushi Division of Organ Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Kato, Shinsuke Division of Neuropathology, Department of Brain and Neuroscience, Faculty of Medicine, School of Medicine, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Maegaki, Yoshihiro Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Keywords
childhood cerebellar tumor
Lhermitte–Duclos disease
mTOR
PTEN
NDC
Natural science
Abstract
We report the case of a 19-year-old female with cerebellar ganglioglioma that was diagnosed at 4 years of age. Despite treatment with partial resection, radiation, and chemotherapy, residual tumor slowly expanded into the brainstem and upper cervical cord, resulting in nocturnal hypopnea, progressive tetraparesis, and feeding difficulty during 8–10 years of age. Initiation of temozolomide and bevacizumab was effective in preventing further expansion of the tumor, and the patient has been treated at home and in school with noninvasive positive pressure ventilation and gastrostomy. Histopathologic examination of the resected tumor tissue revealed phospho-S6-positive tumor cells of either neuronal or astroglial appearance. This suggests that a higher proportion of cells of glial lineage could be linked to the progression of cerebellar ganglioglioma in childhood. Possible treatment options with mammalian target of rapamycin inhibitors are discussed.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
60
Issue
4
Start Page
255
End Page
259
Published Date
2018-02-05
Text Version
Publisher
Citation
Yonago Acta Medica. 2017, 60(4), 255-259
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English