File
Authors
Keywords
bladder function
estrogen
rat
Abstract
The effects of estradiol (E2) on urodynamic parameters were studied with twenty 16-month-old female Wistar rats. They were divided into 4 groups, i.e., Group I: untreated; Groups II and III: treated with E2 for 4 and 8 weeks, respectively; Group IV: treated with a placebo for 8 weeks. After treatment, we measured their plasma E2 levels, and recorded their voiding behavior for 24 h. Cystometry was performed and urodynamic parameters were analyzed. Particularly, bladder capacity as well as voided volume and frequency were surveyed. The results obtained were compared among groups. Levels of bladder capacity in the E2-replaced groups (Groups II, 0.52 ± 0.14 mL and Groups III, 0.58 ± 0.09 mL) were significantly (P < 0.05) higher than in the other groups (Group I, 0.38 ± 0.09 mL and Group IV, 0.40 ± 0.11 mL) respectively. The average voided volume was significantly (P < 0.05) higher in the E2-replaced groups (Groups II, 1.06 ± 0.22 mL and Groups III, 1.01 ± 0.16 mL) than in Group IV (0.79 ± 0.15 mL), respectively. Concerning the number of daily micturition per day, a significant difference (P < 0.05) was observed only between Group III (14.2 ± 2.7) and Group IV (18.8 ± 3.7). This suggests that E2-replacement therapy positively affects bladder function.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
48
Issue
1
Start Page
27
End Page
31
Published Date
2005-03
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 2005, 48(1), 27-31
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English