File
Authors
Keywords
estradiol
major pelvic ganglia
ovariectomy
puberty
Abstract
To elucidate the effect of estradiol (E2) on the morphology of the neurons of the lower urinary tract during puberty, we carried out morphometric and immunohistochemical analyses of the major pelvic ganglia (MPG) in female rats. Four-week-old female Wistar rats were divided into the following groups: normal controls, ovariectomies, and ovariectomies receiving E2 replacement. At the age of 12 weeks the MPG were stained with hematoxylin and eosin (H&E), and immunostained by the antibody against rat tyrosine hydroxylase (TH). Each section was evaluated by an image analysis system. In the ovariectomized rats, the size of neurons in the MPG was significantly reduced. Immunohistochemical analysis revealed that the size of TH-positive neurons was significantly increased compared with TH-negative neurons in the E2-replaced rats. The results suggest that pubertal estrogen deficit reduces the size of neurons in the MPG and that estrogen replacement increases neuron size, especially the adrenergic neurons in the MPG.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
41
Issue
1
Start Page
17
End Page
22
Published Date
1998-03
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 1998, 41(1), 17-22
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English