File
Authors
Keywords
case-control study
Crohn's disease
feeding during infancy
inflammatory bowel disease
ulcerative colitis
Abstract
An epidemiological survey was performed from 1979 to 1993 on Japanese patients who developed ulcerative colitis (UC) or Crohn's disease (CD) during childhood. A case-control study was also conducted concurrently in order to assess whether artificial feeding during infancy (up to 4 months after birth) could be a risk factor for these diseases. The cumulative number of patients until 1993 was 578 cases for UC (sex ratio, 1.1:1.0) and 260 cases for CD (sex ratio, 1.4:1.0). There was almost no change in the number of new cases of UC and CD per year after 1978, showing cases of around 32 (mean ± SD; 32.1 ± 6.8) per year for UC and 16 (15.7 ± 6.3) per year for CD. A case-control study was performed on 133 cases of UC and 42 cases of CD. The 2 × 2 contingency tables were prepared to calculate the odds ratio, significance and 95% confidence interval. Comparison between the group fed exclusively by breast milk or mixed, and the group fed by artificial (bottle) feeding alone for the development of inflammatory bowel disease, showed the following results: in UC, the odds ratio was 0.53 and the 95% confidence interval was 0.31 to 0.89; and in CD, the odds ratio was 0.30 and the 95% confidence interval was 0.13 to 0.70. These results indicated that breast feeding during infancy until postnatal 4 months might decrease the development of chronic inflammatory bowel disease.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
42
Issue
1
Start Page
95
End Page
102
Published Date
1999-03
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 1999, 42(1), 95-102
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English