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Authors
Harada, Tasuku Department of Obstetrics and Gynecology, School of Medicine, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Ohta, Ikuko Department of Obstetrics and Gynecology, Kurashiki Heisei Hospital
Endo, Yusuke Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital Tottori University Researchers
Sunada, Hiroshi Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital Tottori University Researchers
Noma, Hisashi Department of Data Science, The Institute of Statistical Mathematics
Taniguchi, Fuminori Department of Obstetrics and Gynecology, School of Medicine, Tottori University Faculty of Medicine Tottori University Researchers KAKEN Search Researchers
Keywords
estrogen receptor
endometriosis
selective estrogen receptor modulator
pelvic pain
open clinical trial
Abstract
[Background]SR-16234 is a selective estrogen receptor modulator (SERM) structurally different from approved SERM and has been reported to have estrogen receptor (ER) α antagonistic activity and strong affinity with a weak partial agonistic activity to ERβ receptor. SR-16234 showed strong inhibitory effects on transplanted endometrial cysts in the endometriosis model of rat and mouse. In this clinical trial, efficacy and safety of SR-16234 have been evaluated in endometriosis patients.
[Methods]This trial was an open-label single arm clinical trial. Ten patients with dysmenorrhea and pelvic pain associated with endometriosis and adenomyosis were enrolled in this trial, and received 40 mg of SR-16234 once daily for 12 weeks. The primary endpoint was the visual analogue scale (VAS) of pelvic pain. The secondary endpoints included dysmenorrhea score, pelvic pain score, objective observations (stiffness of Douglas’ pouch, limitation of uterine movement, size of ovarian chocolate cysts, thickness of endometrium, and serum CA125 concentration) and safety.
[Results]After oral administration of SR-16234 40 mg for 12 weeks, there were statistically significant decreases in pelvic pain VAS, total pelvic pain score, total dysmenorrhea score, stiffness of Douglas’ pouch, limitation of uterine movement compared with the baseline values.
[Conclusion]The present trial suggested that a selective estrogen receptor modulator could be used for treatment of pain associated with endometriosis for the first time.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
60
Issue
4
Start Page
227
End Page
223
Published Date
2018-02-05
Text Version
Publisher
Citation
Yonago Acta Medica. 2017, 60(4), 227-223
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English