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Title Alternative
特発性間質性肺炎の急性増悪の治療のための白血球除去療法 : パイロット研究
Authors
Keywords
acute exacerbation
idiopathic interstitial pneumonia
idiopathic pulmonary fibrosis
leukocytapheresis
nonspecific interstitial pneumonia
NDC
Natural science
Abstract
Objective: Idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous diffuse parenchymal lung disorders of unknown etiology. An acute exacerbation (AE) is an acute respiratory deterioration that occurs in IIPs. The prognosis of AE of IIPs (AE-IIPs) is extremely severe; however, no established therapies exist. We aimed to evaluate the efficacy of leukocytapheresis (LCAP) to treat patients with AE-IIPs. Patients and Methods: Six chronic IIPs patients who developed AE were enrolled in this study. We performed LCAP on days 2, 3, 9 and 10 in all six patients. All patients were also treated with high-dose corticosteroids and a continuous administration of low-molecular-weight heparin. We observed 30-day survival after the diagnosis of AE to evaluate the efficacy of LCAP. We also assessed oxygenation, high-resolution computed tomography (HRCT) findings, and certain chemical mediators in the peripheral blood. Results: Five of six patients survived more than 30 days. One patient died of progressive respiratory failure. Oxygenation and HRCT findings tended to improve in all survivors. The serum levels of lactate dehydrogenase, high mobility group box-1, and interleukin-18 were significantly decreased statistically post-LCAP. No severe adverse events occurred. Conclusion: We suggest that LCAP is a safe and effective therapy for treating patients with AE-IIPs. J. Med. Invest. 64: 110-116, February, 2017
Content Type
Thesis or Dissertation
Link
Current Journal Title
Published Date
2018-03-01
Publisher-DOI
Text Version
ETD
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。
Citation
This research was published by The Journal of Medical Investigation: YAMAMOTO, Akihiro, et al. Leukocytapheresis for the treatment of acute exacerbation of idiopathic interstitial pneumonias: a pilot study. The Journal of Medical Investigation, 2017, 64.1.2: 110-116.
Language
English
Grant ID
甲第876号
Granted Date
2018-03-01
Degree Name
博士(医学)
Grantor
鳥取大学