File
Authors
Keywords
haloperidol
postoperative delirium
Abstract
Postoperative delirium has in recent years been a common complication which can interfere with the recovery of patients after surgery. Unfortunately there is still no medical procedure available which can completely prevent the occurrence of postoperative delirium. Haloperidol is a psychopharmacological agent that has been used to treat the delirium and agitation, especially in geriatric patients. To assess the effectiveness and safety of the use of haloperidiol for the reduction of postoperative delirium, we performed a randomized, comparative clinical study in which 78 patients who underwent gastrointestinal surgery received either 5 mg of haloperidol intravenously postoperatively at 21:00 for 5 consecutive days, or normal saline with the same schedule. Postsurgical evaluation revealed the incidence of postoperative delirium to be only 10.5% (4 of 38 patients) in the group receiving haloperidol treatment, compared to 32.5% (13 of 40 patients) in the saline treatment group. No significant neuroleptic side effects were seen in any of the patients. These results suggest that daily postoperative administration of haloperidol can reduce the occurrence of postoperative delirium safely.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
42
Issue
3
Start Page
179
End Page
184
Published Date
1999-11
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 1999, 42(3), 179-184
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English