フルテキストファイル
著者
Yamamoto Manabu Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Saito Hiroaki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Uejima Chihiro Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Tanio Akimitsu Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Tada Yoichiro Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Matsunaga Tomoyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧
Sakamoto Teruhisa Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧
Honjo Soichiro Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧
Ashida Keigo Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Fujiwara Yoshiyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
キーワード
carcinoembryonic antigen
colorectal cancer
Controlling Nutritional Status score
prognosis
抄録
Background Nutritional status is strongly associated with prognosis in cancer patients. Controlling Nutritional Status (CONUT) score is a nutritional marker based on serum albumin, cholesterol, and total lymphocyte count. We investigated the prognostic significance of a combination of the tumor marker carcinoembryonic antigen (CEA) and CONUT score (T-CONUT) in colorectal cancer (CRC) patients.

Methods A total of 522 patients who underwent surgery for CRC at our hospital were retrospectively enrolled in this study.

Results Patients were divided into groups based on the results of receiver operating characteristic (ROC) curve analysis as follows: CONUThigh (CONUT score ≥ 3) and CONUTlow (CONUT score < 3), and CEAlow (< 5 ng/mL) and CEAhigh (≥ 5 ng/mL). The 5-year overall survival (OS) rates of patients in the CONUTlow and CONUThigh groups were 76.0% and 53.9%, respectively (P < 0.0001), and in the CEAlow and CEAhigh groups were 80.7% and 47.6%, respectively (P < 0.0001). Regarding T-CONUT, the 5-year OS rates of patients with CEAlow/CONUTlow, CEAlow/CONUThigh, CEAhigh/CONUTlow, and CEAhigh/CONUThigh were 84.7%, 69%, 55.3%, and 36.1%, respectively (P < 0.0001). Multivariate analysis identified T-CONUT score as an independent prognostic indicator in CRC patients.

Conclusion T-CONUT may be a useful tool for predicting prognosis in CRC patients.
出版者
Tottori University Medical Press
資料タイプ
学術雑誌論文
外部リンク
ISSN・ISBN
05135710
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
62
1
開始ページ
124
終了ページ
130
発行日
2019-03-28
出版者DOI
著者版フラグ
出版社版
著作権表記
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
掲載情報
Yonago Acta Medica. 2019, 62(1), 124-130
部局名
医学部・医学系研究科・医学部附属病院
言語
英語