フルテキストファイル
著者
Hirooka Yasuaki Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Aika Noriko Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine
Ishisugi Takuya Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine
Ohguri Masayoshi Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine 研究者総覧
Nagashima Chiharu Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine
Morishita Shota Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine
Kato Yosuke Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine
Fukuda Chisako Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine KAKEN
キーワード
breast
cancer
elastography
mass screening
ultrasonography
抄録
Helminth parasites are known to elicit the immune response towards T helper 2 (Th2)-type, characterized by Th2 related cytokines, that typically include interleukin-4 (IL-4), IL-5 and IL-13. In this review we will describe the mechanisms involved in helminth induced Th2 immune response. Intestinal epithelial cells (IECs) produce thymic stromal lymphopoietin (TSLP), which is both necessary and sufficient for the initiation of Th2 cytokine-driven inflammation. IL-33 mRNA is expressed early during parasite infection and IL-33 binds ST2 receptor, both of which are associated with optimal CD4+ Th2 polarization. Following innate immune cell recognition, basophils and mast cell can secrete Th2 type cytokines that are thought to contribute to CD4+ Th2 differentiation. Additionaly, dendritic cell conditioned with some helminth products can promote CD4+ Th2 differentiation. Alternatively activated macrophages, activated by the Th2 cytokines IL-4 and IL-13 in parasitic infections, contribute to the host protective response: control of Th1-type inflammation, wound healing and worm expulsion. Experimentally, helminths have been associated with protection against a number of autoimmune disorders, including inflammatory bowel diseases and type 1 diabetes. It may be a novel strategy to ameliorate autoimmune inflammation by expanding and activating the Th2 response originated from parasites.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
52
4
開始ページ
115
終了ページ
120
発行日
2009-12
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2009, 52(4), 115-120
言語
英語