フルテキストファイル
著者
Miki Norio Clinic of Ophthalmology, Miki Eye Clinic
Nakao Hiroshi Clinic of Ophthalmology, Nakao Eye Clinic
Hasegawa Jiro Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Baba Takashi Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Ishikura Ryoko Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Kakimaru Akiko Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Sakatani Keiko Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Yamasaki Atsushi Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Sasaki Yuji Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Tamai Akihiko Clinic of Ophthalmology, Hino Hospital Association Hino Hospital KAKEN研究者をさがす
キーワード
D2-selective dopamine receptor antagonist
dopamine
electrooculogram
fast oscillation
metoclopramide hydrochloride
抄録
Fast oscillation (FO) of an electrooculogram (EOG) was recorded in both eyes of 10 healthy volunteers before and after administration of metoclopramide hydrochloride (MTCL), a D2-selective dopamine receptor antagonist, paying particular attention to sex concerning sensitivity to dopamine in young subjects. Healthy volunteers were divided into male and female groups; 5 males (10 eyes) aged 21 to 23 years (average, 21.8 years) and 5 females (10 eyes) aged 19 to 25 years (average, 21.8 years). As an FO parameter, the dfFO (the averaged difference in ?V between maximum amplitude in the dark period and minimum amplitude in the light period during FO measurement) was evaluated. The mean level of dfFO significantly increased between phase A (the initial 10 min before intravenous injection of 10 mg of MTCL) and phase B (10 min after the injection) in the male and female groups (P < 0.01 and P < 0.025) and between phase A and phase C (the additional 10 min after the injection) in both groups (P < 0.01 and P < 0.05). The mean level of dfFO in the female group was significantly higher than that of the male group in phase B (P < 0.05). As a control, the experimental procedure was performed with physiological saline administration, and no changes were observed. The data suggest that there exists some difference between young males and females generation concerning sensitivity to dopamine and that young females may show a higher-than-male sensitivity to dopamine in the occurrence of FO potential.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
48
4
開始ページ
83
終了ページ
92
発行日
2005-12
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2005, 48(4), 83-92
部局名
医学部・医学系研究科・医学部附属病院
言語
英語