フルテキストファイル
著者
Matsuura Kazunori Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University 鳥取大学研究者総覧 KAKEN研究者をさがす
Mizuguchi Yusaku Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
Kimizuka Nobuo Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
キーワード
viral capsid
self-assembly
β-annulus peptide
nanosphere
抄録
A novel β-annulus peptide of Sesbania mosaic virus bearing an FKFE sequence at the C terminus was synthesized, and its self-assembling behavior in water was investigated. Dynamic light scattering and transmission electron microscopy showed that the β-annulus peptide bearing an FKFE sequence self-assembled into approximately 30 nm nanospheres in water at pH 3.8, whereas the β-annulus peptide without the FKFE sequence afforded only irregular aggregates. The peptide nanospheres possessed a definite critical aggregation concentration (CAC = 26 μM), above which the size of nanospheres were nearly unaffected by the peptide concentration. The formation of peptide nanospheres was significantly affected by pH; the peptide did not form any assemblies at pH 2.2 whereas larger aggregates were formed at pH 6.4–11.6.
出版者
Wiley
資料タイプ
学術雑誌論文
外部リンク
ISSN・ISBN
00063525
書誌ID
AA11029495
掲載誌名
Biopolymers. Peptide science
最新掲載誌名
Biopolymers. Peptide science
106
4
開始ページ
470
終了ページ
475
発行日
2015-11-17
出版者DOI
著者版フラグ
著者版
著作権表記
© 2015 Wiley Periodicals, Inc.
掲載情報
This is the pre-peer reviewed version of the following article: Matsuura, K. , Mizuguchi, Y. and Kimizuka, N. (2016), Peptide nanospheres self‐assembled from a modified β‐annulus peptide of Sesbania mosaic virus. Biopolymers, 106: 470-475. which has been published in final form at https://doi.org/10.1002/bip.22774. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
部局名
工学部・工学研究科
言語
英語