フルテキストファイル
著者
Yamada Takeshi Division of Neoropsychiatry, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
Ikuta Kazufumi Division of Biosignaling, Department of Biomedical Sciences, School of Life Sciences, Tottori University Faculty of Medicine
Kawahara Ryuzo Division of Neoropsychiatry, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
Sairenji Takeshi Division of Biosignaling, Department of Biomedical Sciences, School of Life Sciences, Tottori University Faculty of Medicine
キーワード
interferon
major depressive disorder
2',5'-oligoadenylate synthetase
抄録
The aim of this study was to measure the activity of 2',5'-oligoadenylate synthetase (2',5'AS) which is mainly induced by interferon (IFN)-α and -β in patients with major depression and evaluate its relationship to the disease. 2',5'AS activity of 23 patients (male = 11, female = 12) with major depression and of 29 normal control subjects (male = 15, female = 14) was measured in peripheral blood mononuclear cells (PBMCs) by radioassay. The mean 2',5'AS activity in the PBMCs of the patients and that of the control subjects were 1.10 ± 0.69% and 0.72 ± 0.51%, respectively. The activity in the patients was statistically higher than that of the control subjects (P = 0.03). These results imply some abnormality in the IFN-2',5'AS system of patients with major depression.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
47
1
開始ページ
1
終了ページ
5
発行日
2004-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2004, 47(1), 1-5
部局名
医学部・医学系研究科・医学部附属病院
言語
英語