フルテキストファイル
著者
Ohno Koyo Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine
Saito Yoshiaki Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Tamasaki-Kondo Akiko Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Kambe Atsushi Division of Neurosurgery, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Horie Yasushi Division of Organ Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Kato Shinsuke Division of Neuropathology, Department of Brain and Neuroscience, Faculty of Medicine, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Maegaki Yoshihiro Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
キーワード
childhood cerebellar tumor
Lhermitte–Duclos disease
mTOR
PTEN
抄録
We report the case of a 19-year-old female with cerebellar ganglioglioma that was diagnosed at 4 years of age. Despite treatment with partial resection, radiation, and chemotherapy, residual tumor slowly expanded into the brainstem and upper cervical cord, resulting in nocturnal hypopnea, progressive tetraparesis, and feeding difficulty during 8–10 years of age. Initiation of temozolomide and bevacizumab was effective in preventing further expansion of the tumor, and the patient has been treated at home and in school with noninvasive positive pressure ventilation and gastrostomy. Histopathologic examination of the resected tumor tissue revealed phospho-S6-positive tumor cells of either neuronal or astroglial appearance. This suggests that a higher proportion of cells of glial lineage could be linked to the progression of cerebellar ganglioglioma in childhood. Possible treatment options with mammalian target of rapamycin inhibitors are discussed.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
60
4
開始ページ
255
終了ページ
259
発行日
2018-02-05
著者版フラグ
出版社版
掲載情報
Yonago Acta Medica. 2017, 60(4), 255-259
部局名
医学部・医学系研究科・医学部附属病院
言語
英語