フルテキストファイル
著者
Matsusue Eiji Department of Radiology, Tottori Prefectural Central Hospital KAKEN研究者をさがす
Fujihara Yoshio Department of Radiology, Tottori Prefectural Central Hospital
Tanaka Kenichiro Department of Neurology, Tottori Prefectural Central Hospital KAKEN研究者をさがす
Aozasa Yuki Department of Neurology, Tottori Prefectural Central Hospital
Shimoda Manabu Department of Neurology, Tottori Prefectural Central Hospital
Nakayasu Hiroyuki Department of Neurology, Tottori Prefectural Central Hospital
Nakamura Kazuhiko Department of Radiology, Tottori Prefectural Central Hospital
Ogawa Toshihide Division of Radiology, Department of Pathophysiological Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine
キーワード
123I-FP-CIT
123I-MIBG
Parkinson’s disease
combined analysis
NDC分類
4類 自然科学
抄録
【Background】123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy and 123I-FP-CIT dopamine transporter single photon emission computed tomography (DAT-SPECT) provide specific information that distinguish Parkinson’s disease (PD) from parkinsonian syndromes other than PD (non-PD), including atypical parkinsonian disorder (APD) and non-PD other than APD (nPD-nAPD). The purpose of this study was to determine whether combining DAT-SPECT and MIBG myocardial scintigraphy using multiparametric scoring system (MSS) could improve diagnostic test accuracy in discriminating PD from APD or discriminating PD from nPD-nAPD.
【Methods】A total of 52 patients, including 36 PD, eight APD and eight nPD-nAPD, underwent both MIBG myocardial scintigraphy and DAT-SPECT, were evaluated. The heart-to-mediastinum (H/M) ratios (early and delayed), washout-rate (WR), the average (Ave) and asymmetry index (AI) of specific binding ratio (SBR) were calculated. Cutoff values were determined, using ROC analysis, for discriminating PD from APD and for discriminating PD from nPD-nAPD, on five parameters. All cases were scored as either 1 (PD) or 0 (nPD-nAPD or APD) for each parameter according to its threshold in each discrimination. These individual scores were summed for each case, yielding a combined score to obtain a cutoff value for the MSS in each discrimination.
【Results】For discriminating PD from nPD-nAPD, the highest accuracy was 80% at a cutoff value of 19% for the WR and a cut off value of 2 improved diagnostic accuracy to 84% for MSS. For discriminating PD from APD, the highest accuracy was 86% at a cutoff value of 2.8 for the H/M ratio (late) and a cut off value of 2 showed diagnostic accuracy of 86% for MSS.
【Conclusion】A MSS has comparable or better accuracy compared to each parameter of MIBG myocardial scintigraphy and DAT-SPECT in distinguishing PD from nPD-nAPD or distinguishing PD from APD.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
外部リンク
http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
61
2
開始ページ
117
終了ページ
127
発行日
2018-06-18
著者版フラグ
出版社版
著作権表記
注があるものを除き、この著作物は日本国著作権法により保護されています。
掲載情報
Yonago Acta Medica. 2018, 61(2), 117-127
部局名
医学部・医学系研究科・医学部附属病院
言語
英語