フルテキストファイル
著者
Tokuyasu Naruo Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine/Division of Organ Pathology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 鳥取大学研究者総覧
Shomori Kohei Division of Organ Pathology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Amano Kuniki Sky Clinic
Honjo Soichiro Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 鳥取大学研究者総覧
Sakamoto Teruhisa Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 鳥取大学研究者総覧
Watanabe Joji Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 鳥取大学研究者総覧
Amisaki Masataka Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Morimoto Masaki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Uchinaka Ei Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Yagyu Takuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Saito Hiroaki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 鳥取大学研究者総覧 KAKEN研究者をさがす
Ito Hisao Division of Organ Pathology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Fujiwara Yoshiyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 鳥取大学研究者総覧 KAKEN研究者をさがす
キーワード
Chinese herbal medicine
DSS-induced colitis model
indirubin
inflammatory bowel disease
Qing-Dai
NDC分類
4類 自然科学
抄録
【Background】Indirubin, a constituent of the Chinese herbal medicine “Qing-Dai,” has anti-cancer and anti-inflammatory activities. We aimed to evaluate the efficacy of indirubin for ameliorating colonic inflammation in a mouse model of inflammatory bowel disease. 【Methods】Mice with dextran sulfate sodium (DSS)induced acute and chronic colitis were treated with indirubin in their diet. Clinical and histologic changes were evaluated. In addition, colon levels of interleukin-6, a critical pro-inflammatory mediator, was detected by enzyme-linked immunosorbent assay. 【Results】In the model of acute colitis, indirubin treatment improved the loss of body weight. Histology of colonic tissue revealed that indirubin treatment improved the histology grading of colitis (P = 0.02), the extent of submucosal fibrosis (P = 0.018), the number of mucosal toluidine blue-positive cells (P = 0.004) and colon length (P = 0.01). In the model of chronic colitis, indirubin treatment had no significant effect on pathologic findings except for colon length (P = 0.003). However, indirubin administration significantly reduced colon levels of interleukin-6 in the chronic-colitis model (P = 0.001). 【Conclusion】Our study clearly showed that oral intake of indirubin can improve murine DSS-induced colitis (which mimics human inflammatory bowel disease).
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
外部リンク
http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
61
2
開始ページ
128
終了ページ
136
発行日
2018-06-18
著者版フラグ
出版社版
著作権表記
注があるものを除き、この著作物は日本国著作権法により保護されています。
掲載情報
Yonago Acta Medica. 2018,61(2), 128-136
部局名
医学部・医学系研究科・医学部附属病院
言語
英語