フルテキストファイル
著者
Sugihara Shinobu Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, School of Medicine, Tottori University, Faculty of Medicine
Kinugasa Yoshiharu Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, School of Medicine, Tottori University, Faculty of Medicine 研究者総覧 KAKEN
Takata Tomoaki Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine 研究者総覧
Sugihara Takaaki Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Hosho Keiko Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Imai Chitose Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine
Ito Hiromi Department of Clinical Radiology, Tottori University Hospital
Yamada Kensaku Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, School of Medicine, Tottori University, Faculty of Medicine
Kato Masahiko Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, School of Medicine, Tottori University, Faculty of Medicine 研究者総覧 KAKEN
Yamamoto Kazuhiro Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, School of Medicine, Tottori University, Faculty of Medicine 研究者総覧 KAKEN
キーワード
acute decompensated heart failure
diuretic resistance
kidney volume
ultrasound examination
抄録
[Background]Diuretics are essential for treating acute decompensated heart failure (ADHF), but the response is inconsistent. This study aimed to clarify whether kidney volume as assessed by ultrasound (US) predicts diuretic resistance in patients with ADHF.
[Methods]We enrolled 29 patients with ADHF and 32 controls. Height-adjusted kidney volume was assessed by US. We divided patients into two groups based on the median value of total daily use of furosemide (intravenous dose plus 0.5 × oral dose of furosemide equivalents) during 3 days from admission.
[Results]Patients with ADHF had a significantly smaller left kidney volume than did control subjects (27.7 ± 10.0 vs. 32.8 ± 8.8 mL/m, P < 0.05). Patients in the highdose furosemide group (≥ 51.7 mg/d) had a significantly lower estimated glomerular filtration rate (eGFR) and a significantly smaller kidney volume than did those in the low-dose furosemide group (eGFR: 43.9 ± 20.4 vs. 60.8± 21.6 mL/min/1.73 m2, left kidney volume: 23.2 ± 5.2vs. 32.6 ± 11.0 mL/m, right kidney volume: 26.5 ± 7.5vs. 32.6 ± 7.9 mL/m, all P < 0.05). Multivariate logistic analysis showed that left kidney volume, but not eGFR,was independently associated with the requirement of high-dose furosemide (odds ratio: 0.856, 95% confidence interval: 0.735–0.997, P < 0.05).
[Conclusion]Kidney volume as assessed by US is a useful predictor of diuretic resistance in patients with ADHF.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
外部リンク
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
60
3
開始ページ
135
終了ページ
144
発行日
2017-09-15
著者版フラグ
出版社版
掲載情報
Yonago Acta Medica. 2017, 60(3), 135-144
部局名
医学部・医学系研究科・医学部附属病院
言語
英語