フルテキストファイル
著者
Qian Weibin Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Department of Lung Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Hasegawa Junichi Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/National Hospital Organization,Yonago Medical Center KAKEN研究者をさがす
Yang Jie Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine
Endo Yusuke Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital 鳥取大学研究者総覧
Miake Junichiro Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine/Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine 鳥取大学研究者総覧 KAKEN研究者をさがす
キーワード
absorption
daijokito
portal vein sampling
ranitidine
rat model
NDC分類
4類 自然科学
抄録
【Background】 Daijokito (DJKT), a classical traditional Kampo and Chinese medicine, has been used to treat acute pancreatitis in China. In our previous study, DJKT was found to reduce the area under the plasma concentration-time curve (AUC) of ranitidine in humans.
Therefore, we established a novel rat model to examine the direct absorption of ranitidine after daijokito administration.
【Methods】 An in situ intestinal injection with portal vein sampling (IIPS) model was created to determine the rate of intestinal drug absorption. Rats were divided into two groups: the ranitidine group (R, n = 6) or the ranitidine and daijokito group (RD, n = 6). Blood was collected after intestinal injection of drugs. After the experiment, the concentrations of ranitidine were measured by LC/MS/MS analysis.
【Results】 The concentrations of ranitidine increased linearly with time in both groups. Compared with the R group, the concentrations of ranitidine in RD group significantly decreased throughout the experiment.
【Conclusion】 Co-administration of ranitidine with DJKT resulted in significant decreases in intestinal absorption in rats. The reduction of the systemic ranitidine concentration by co-administration of DJKT may be due, at least in part, to the inhibition of intestinal absorption
of ranitidine.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
13468049
書誌ID
AA00892882
掲載誌名
Yonago Acta Medica
最新掲載誌名
Yonago Acta Medica
61
4
開始ページ
192
終了ページ
196
発行日
2018
著者版フラグ
出版社版
掲載情報
Yonago Acta Medica. 2018, 61(4), 192-196
部局名
医学部・医学系研究科・医学部附属病院
言語
英語