フルテキストファイル
著者
Taniguchi Kenjiro Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Tsujitani Shunichi Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Tokuyasu Naruo Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 鳥取大学研究者総覧
Naka Takuji Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Tatebe Shigeru Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Kondo Akira Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Ikeguchi Masahide Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
キーワード
gastric carcinoma
prognosis
RhoA
ROCK-1
抄録
A small GTPase Rho protein and an effector ROCK have significant roles in cancer adhsion, metastasis, invasion, angiogenesis and cell mortality. We investigated the expressions of RhoA protein and ROCK-1 protein in 100 patients with macroscopically T3/T4 gastric cancer immunohistochemically. The expression of RhoA was detected in gastric cancer specimens from 39 patients and that of ROCK-1 in specimens from 30 patients. The clinicopathological characteristics of 21 tumors with co-expression of RhoA and ROCK-1 proteins (Rho/ROCK ON) were compared with those of the 79 remaining tumors (Rho/ROCK OFF). The percentage of lymph node metastasis positive cases in the Rho/ROCK ON group (81%) was higher than that in the Rho/ROCK OFF group (66%), but the difference was not significant (P = 0.183). However, the prognosis of the 21 patients with Rho/ROCK ON was significantly poorer than that of the 79 with Rho/ROCK OFF (P = 0.006). Our results indicate that the evaluation of the protein expression of RhoA and ROCK-1 is useful for predicting the prognosis in patients with T3/T4 gastric cancer.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
50
1
開始ページ
9
終了ページ
15
発行日
2007-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2007, 50(1), 9-15
部局名
医学部・医学系研究科・医学部附属病院
言語
英語