フルテキストファイル
著者
Baba Takashi Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Sasaki Yuji Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Hatta Shiro Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Hasegawa Jiro Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Yamasaki Atsushi Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine KAKEN研究者をさがす
Ishikura Ryoko Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Kakimaru Akiko Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Matsuura Kazuki Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Sciences
Tamai Akihiko Clinic of Ophthalmology, Hino Hospital Association Hino Hospital KAKEN研究者をさがす
キーワード
diabetic retinopathy
macular function
multifocal electroretinogram
optical coherence tomogram
panretinal photocoagulation
抄録
We evaluated macular function before and after panretinal photocoagulation (PRP) in diabetic retinopathy using a multifocal electroretinogram (mfERG) and optical coherence tomogram (OCT). In mfERGs, the 1st positive wave (P1) minus the 1st negative wave (N1) amplitude (P1 ? N1 amplitude), the P1 peak latency and the response density were measured in 7, 19, 37 and 103 hexagonal areas or elements (Areas 1, 2, 3 and 4) within a central radius of 5, 7, 10 and 20 degrees, respectively. The mean retinal thickness was estimated from 9 calculation points at the foveal region within 5 degrees; the central and each of the other 4 points at a distance of 250 ?m and 500 ?m from the central por tion on horizontal and vertical sections on OCT. The P1 peak latencies from the 4 areas were remarkably prolonged in 14 eyes of 9 patients with preproliferative or early proliferative diabetic retinopathy showing no clinically significant macular edema before PRP as compared with those in 15 normal control eyes, without a tendency of recovery throughout the course after PRP except for area 1. The P1-N1 amplitudes and the mean response density levels from the 4 areas were remarkably decreased in the diabetic eyes before PRP as compared with those in the control eyes, followed by a maximum decrease in both parameters at 3 months after PRP. However, remarkable recoveries were detected in both decreased parameters from the 4 areas at 6 months after PRP. The mean foveal retinal thickness on OCT was remarkably increased in the diabetic eyes before PRP as compared with the thickness in 16 normal control eyes. Most remarkably, a transient increase in thickness was detected in diabetic eyes 1 month after PRP, followed by a tendency of recovery 3 to 6 months after PRP. These results indicate that mfERG and OCT examinations are useful in the assessment of macular function before and after PRP in diabetic retinopathy, especially within 5 degrees of the central portion, and that the effects of PRP on macular function in this entity seem to be reversible at the foveal region, although we need to do further investigation in relation to the outcome of visual acuity.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
47
4
開始ページ
71
終了ページ
79
発行日
2004-12
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2004, 47(4), 71-79
部局名
医学部・医学系研究科・医学部附属病院
言語
英語