ID 11617
File
Authors
Narai, Satoshi Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University
Kawashima-Sonoyama, Yuki Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University Researchers DB KAKEN
Fujimoto, Masanobu Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University Researchers DB
Miura, Mazumi Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University Researchers DB
Adachi, Kaori Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University Researchers DB KAKEN
Nanba, Eiji Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University Researchers DB KAKEN
Namba, Noriyuki Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University Researchers DB KAKEN
Keywords
hypoglycemia
insulin/IGF-1 signaling
preterm
small-for-gestational age
Abstract
[Background] Insulin and insulin-like growth factor (IGF) signaling plays an important role in prenatal and postnatal growth and glucose metabolism. Both small-for-gestational age (SGA) and preterm infants have abnormal growth and glucose metabolism. However, the underlying mechanism remains unknown. Recently, we showed that term SGA infants have abnormal insulin/IGF signaling in cord blood. In this study, we examined whether preterm infants show similar aberrations in cord blood insulin/IGF signaling. [Methods] A total of 41 preterm cord blood samples were collected. Blood glucose, insulin, IGF-1, and C-peptide concentrations were measured, and mRNA expression of IGF1R, INSR, IRS1, IRS2, and SLC2A4 (i.e., GLUT4) was analyzed by quantitative reverse-transcription PCR. [Results] This study included 34 appropriate-for-gestational age (AGA) and 7 SGA preterm neonates. No hyperinsulinemia or any differences in IGF1R or INSR mRNA expression were detected between the two groups. However, GLUT4 mRNA levels were increased in preterm SGA. Moreover, the expression level in hypoglycemic preterm SGA was significantly higher than that in hypoglycemic preterm AGA. IRS2 mRNA expression did not show a statistically significant difference between preterm SGA and AGA neonates. [Conclusion] SGA preterm birth does not induce hyperinsulinemia; however, it modifies insulin/IGF signaling components such as GLUT4 in umbilical cord blood. Our study suggests that prematurity or adaptation to malnutrition alters the insulin/IGF signaling pathway.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN
05135710
EISSN
13468049
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
64
Issue
1
Start Page
57
End Page
66
Published Date
2021-02-22
Publisher-DOI
Text Version
Publisher
Rights
(C) 2021 Tottori University Medical Press
Citation
S. Narai, Y. Kawashima-Sonoyama, M. Fujimoto, et al. Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression. Yonago Acta Medica. 2021, 64(1), 57-66. doi:10.33160/yam.2021.02.009
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English