ID 14057
File
Authors
Ikeda, Suguru Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University
Sugihara, Takaaki Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University Researchers DB KAKEN
Kihara, Takuya Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University
Hoshino, Yoshiki Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University
Matsuki, Yukako Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University
Nagahara, Takakazu Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University Researchers DB
Oyama, Kenji Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University Researchers DB
Okano, Jun-ichi Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University Researchers DB KAKEN
Kuwamoto, Satoshi Department of Pathology, Tottori University Hospital Researchers DB KAKEN
Horie, Yasushi Department of Pathology, Tottori University Hospital Researchers DB KAKEN
Isomoto, Hajime Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University Researchers DB KAKEN
Keywords
autoimmune hepatitis
chronic active EBV infection
EBV-encoded small RNA1
Epstein–Barr virus
Abstract
Chronic active Epstein–Barr virus (CAEBV) infection is a rare disease, mainly affecting children, typically characterized by persistent infectious mononucleosis (IM)-like symptoms. We describe an adult case of CAEBV without IM-like symptoms, which was indistinguishable from autoimmune hepatitis (AIH). A 60-year-old woman with liver damage was diagnosed with AIH (International Diagnostic Score: 16 points). She had been treated with prednisolone for three years; however, her transaminases had never normalized. She was admitted for another liver biopsy due to repeated high fevers and worsening of her liver damage over two months. Her EBV-DNA copy number was 2.9 × 104 copies/μg DNA, and EBV-encoded small RNA1-positive lymphocytic infiltration was observed in both the present and previously collected (three years ago) liver tissue samples. This case implies that hepatic involvement in a CAEBV without IM-like symptoms is difficult to distinguish from AIH and may be misdiagnosed. In some steroid resistant AIH cases, evaluating for CAEBV may be valuable.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN
05135710
EISSN
13468049
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
65
Issue
2
Start Page
160
End Page
165
Published Date
2022-05-23
Publisher-DOI
Text Version
Publisher
Rights
(C) 2022 Tottori University Medical Press.
Citation
Yonago Acta Medica. 2022, 65(2), 160-165. doi10.33160/yam.2022.05.003
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English