ID | 5480 |
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Authors | |
Keywords | activation-induced cytidine deaminase
Merkel cell carcinoma
Merkel cell polyomavirus
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Abstract | [Background] Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and-negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma(HCV), and Burkitt lymphoma (EBV). [Methods] To elucidate the relation of aberrant AID expression in MCPyV-positive and -negative MCCs, we evaluated immunohistochemical expressions of AID and AID-regulating factors between 24 MCPyV-positive and 17 MCPyV-negative MCCs. [Results] AID expression was significantly higher in MCPyV-negative MCCs than MCPyV-positive ones (P = 0.026), although expression of NF-κB p65 (phospho S536) (AID-enhancer) was significantly higher in MCPyV-positive MCCs than MCPyV-negative ones (P = 0.034). Expressions of PAX5 and c-Myb were not significantly different between these subgroups. Expressions of AID and AID-regulating factors were not correlated to prognosis of MCC patients. [Conclusion] Our findings suggest that although pathogen-induced AID expression through upregulationof NF-κB may be relevant to carcinogenesis of MCPyV-positive MCCs, the significantly higher aberrant AID expression in MCPyV-negative MCCs is consistent with the fact that MCPyV-negative MCCs have an extremely extremely higher mutation burden than MCPyV-positive ones.
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Publisher | Tottori University Faculty of Medicine
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Content Type |
Journal Article
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Link | |
ISSN | 0513-5710
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EISSN | 1346-8049
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NCID | AA00892882
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Journal Title | Yonago Acta Medica
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Current Journal Title |
Yonago Acta Medica
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Volume | 60
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Issue | 3
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Start Page | 145
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End Page | 153
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Published Date | 2017-9-15
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Publisher
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Rights | 注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
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Citation | Yonago Acta Medica. 2017, 60(3), 145-153
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Department |
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
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Language |
English
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Web of Science Key ut | WOS:000417029800002
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