ID 5721
File
Authors
Nakamura, Yoko Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University
Yamada, Saki Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University
Nishikawa, Shoko Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University
Matsuura, Kazunori Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University Researchers DB KAKEN
Abstract
β-Annulus peptides from tomato bushy stunt virus conjugated with DNAs (dA20 and dT20) at the C-terminal were synthesized. The DNA-modified β-annulus peptides self-assembled into artificial viral capsids with sizes of 45-160 nm. ζ-Potential measurements revealed that the DNAs were coated on the surface of artificial viral capsids. Fluorescence assays indicated that the DNAs on the artificial viral capsids were partially hybridized with the complementary DNAs. Moreover, the DNA-modified artificial viral capsids formed aggregates by adding complementary polynucleotides.
Publisher
Wiley
Content Type
Journal Article
Link
ISSN・ISBN
10991387
NCID
AA11623882
Journal Title
Journal of peptide science
Current Journal Title
Journal of peptide science
Volume
23
Issue
7-8
Start Page
636
End Page
643
Published Date
2017-08-07
Publisher-DOI
Text Version
Author
Rights
Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.
Citation
This is the peer reviewed version of the following article: Nakamura Y, Yamada S, Nishikawa S, Matsuura K, DNA-modified Artificial Viral Capsids self-assembled from DNA-conjugated β-Annulus Peptide. Journal of peptide science. 2017, 23, 636 , which has been published in final form at https://doi.org/10.1002/psc.2967. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Department
Faculty of Engineering/Graduate School of Engineering
Language
English