ID 6596
File
Authors
Wakumoto, Keiko Division of Dermatology, Matsue Red Cross Hospital
Yoshida, Yuichi Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Yamamoto, Osamu Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
Keywords
basal cell carcinoma
inherited ichthyosis
X-linked recessive ichthyosis
Abstract
We report a case of X-linked recessive ichthyosis with basal cell carcinoma. An 86-year-old man was referred to our department for evaluation of a 1-year history of an ulcer on his left leg. He had suffered from dry skin with scales on his entire body since childhood. Histopathological examination of the lower leg revealed intradermal proliferation of a solid nest of basaloid cells showing unclear palisading in the periphery. Marked hyperkeratosis and hypergranulosis were also seen in the adjacent dermis. Loss of the steroid sulfatase gene was found on chromosome X. Based on these finding, we made a diagnosis of X-linked recessive ichthyosis with basal cell carcinoma. To our knowledge, there has been no report of X-linked recessive ichthyosis with cutaneous malignancy. We discuss the risk of skin cancer in relation to ichthyosis.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN
05135710
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
63
Issue
1
Start Page
92
End Page
94
Journal Section
Patient Report
Published Date
2020-02-20
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Keiko Wakumoto, Yuichi Yoshida, Osamu Yamamoto, Is X-linked Recessive Ichthyosis a High Risk for Basal Cell Carcinoma?, Yonago Acta Medica, 2020, Volume 63, Issue 1, Pages 92-94, Released February 20, 2020
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English