ID 7493
File
Authors
Kawasaki, Makoto Division of Oral Maxillofacial Surgery, Department of Sensory and Motor of Organs, School of Medicine, Factory of Medicine, Tottori University
Tamura, Takayuki Division of Oral Maxillofacial Surgery, Department of Sensory and Motor of Organs, School of Medicine, Factory of Medicine, Tottori University Researchers DB
Harada, Yusei Division of Oral Maxillofacial Surgery, Department of Sensory and Motor of Organs, School of Medicine, Factory of Medicine, Tottori University
Fujii, Nobuyuki Division of Oral Maxillofacial Surgery, Department of Sensory and Motor of Organs, School of Medicine, Factory of Medicine, Tottori University Researchers DB
Doi, Rieko Division of Oral Maxillofacial Surgery, Department of Sensory and Motor of Organs, School of Medicine, Factory of Medicine, Tottori University
Kodani, Isamu Division of Oral Maxillofacial Surgery, Department of Sensory and Motor of Organs, School of Medicine, Factory of Medicine, Tottori University Researchers DB KAKEN
Keywords
carcinoma
squamous cell
mouth neoplasms
neoplasms
multiple primary
Abstract
[Background] Owing to the increase in the older population and the increased life span, the number of patients with oral multiple primary carcinomas will increase. Predicting the second and third carcinoma clinically is difficult, and the presence of second or third carcinomas is a factor that determines the prognosis of oral carcinoma. In this study, we examined the clinical features of oral multiple primary carcinomas treated in our department. [Methods] We retrospectively reviewed the medical records of patients with oral squamous cell carcinoma who underwent radical treatment at and were followed by the Department of Oral and Maxillofacial Surgery, Tottori University Hospital from January 2003 to October 2017. [Results] This study included 261 patients: 241 patients had oral single primary carcinoma and 20 patients had oral multiple primary carcinomas. Oral multiple primary carcinomas showed female predilection and occurred more frequently in the lower gingiva and significantly less frequently in the tongue (P < 0.01). Oral multiple primary carcinomas showed a significantly higher recurrence rate (P < 0.01). The 5-year overall survival of oral single primary carcinoma patients was 88.0% compared with 95% for oral multiple primary carcinomas, with no significant difference (log rank test, P = 0.54). However, the 15-year survival rate dropped to 28.1% in oral multiple primary carcinomas. The cumulative disease incidence rates of metachronous second primary carcinoma from first carcinoma at 5 years and 10 years were 3.45% and 5.36%, respectively. [Conclusion] Oral multiple primary carcinomas rarely occur in the tongue. The 5-year survival rate showed no difference between single and multiple carcinoma patients, but over longer observation, the prognosis of multiple carcinoma was poor owing to a high recurrence rate. Because of the high recurrence rate and risk of further metachronous carcinoma in oral multiple primary carcinomas, longer-term follow-up is required.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN
0513-5710
EISSN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
63
Issue
4
Start Page
246
End Page
254
Journal Section
Original Articles
Published Date
2020-11-24
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Kawasaki Makoto, Tamura Takayuki, Harada Yusei, et al. Clinical Features of Oral Multiple Primary Carcinomas Compared with Oral Single Primary Carcinoma. Yonago Acta Medica. 2020, 63(4). 246-254. doi:10.33160/yam.2020.11.002
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English