ID 7507
File
Authors
Masumoto, Toshio Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine, Tottori University Researchers DB
Onishi, Kazunari Division of Environmental Health Sciences, Graduate School of Public Health, St. Luke’s International University KAKEN
Harada, Tasuku Department of Obstetrics and Gynecology, Research Center for Bioscience and Technology, Faculty of Medicine, Tottori University Researchers DB KAKEN
Amano, Hiroki Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine, Tottori University Researchers DB KAKEN
Otani, Shinji International Platform for Dryland Research and Education, Tottori University Researchers DB KAKEN
Kurozawa, Youichi Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine, Tottori University Researchers DB KAKEN
Keywords
anxiety disorder
endometriosis
oxytocin
Abstract
[Background] Oxytocin has a key role in mother-infant bonding, maternal care, social interaction, and stress-related psychiatric disorders. However, the factors determining oxytocin concentrations during and after pregnancy such as medical history related to nursing or parental behavior are unknown. To elucidate these, we analyzed the relationships between oxytocin concentrations during and after pregnancy, and medical history assessed in the Japan Environment and Children’s Study (JECS). [Methods] We then selected the pregnant women with a medical history of anxiety disorder and endometriosis as cases and pregnant women without medical history as controls adjusting the cohort for age and parity for a nested case-control study, after which 162 women remained for analysis. We evaluated 162 pregnant women from JECS using answers provided in a questionnaire and by measuring plasma oxytocin concentration by ELISA during the first (T1) and second (T2) trimesters of pregnancy, and after childbirth (T3). [Results] Oxytocin concentration increased in a time dependent manner, consistent with previous reports. There were weak negative correlations between oxytocin concentration at T1 and the mother’s age and height, but no correlation with other factors. The mean oxytocin concentrations of pregnant women with a history of an anxiety disorder (n = 7) and endometriosis (n = 13) were significantly lower than those of pregnant women with no such history at T2 and T3. [Conclusion] These results suggest that oxytocin concentrations during and after pregnancy were affected by a past history of anxiety disorder and endometriosis. This is the first study of the relationship between oxytocin concentration and endometriosis. To elucidate the molecular mechanisms, further study is needed.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN
0513-5710
EISSN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
63
Issue
4
Start Page
301
End Page
307
Journal Section
Original Articles
Published Date
2020-11-24
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Masumoto Toshio, Onishi Kazunari, Harada Tasuku, et al. Plasma Oxytocin Concentrations During and After Gestation in Japanese Pregnant Women Affected by Anxiety Disorder and Endometriosis. 2020, 63(4). 301-307. doi:10.33160/yam.2020.11.012
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English