ID 8277
File
Authors
Hosoda, Yuzuru Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine / Department of Hematology, Tottori University Hospital Researchers DB
Hagino, Hiroshi Division of Rehabilitation, Tottori University Hospital Researchers DB KAKEN
Hino, Norihiko Department of Hematology, Tottori University Hospital
Motokura, Toru Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine / Department of Hematology, Tottori University Hospital Researchers DB KAKEN
Keywords
bendamustine
Evans syndrome
immune thrombocytopenia
splenomegaly
rheumatoid arthritis
Abstract
Chemotherapy for lymphoma may be avoided in the presence of coincident cytopenia. In case of immune cytopenia secondary to lymphoma, treatment of cytopenia is the same for primary cases, however, chemotherapy for lymphoma may be effective at the cost of severe hematological toxicity. The present study reports a complex case of thrombocytopenia and direct antiglobulin test‑negative hemolytic anemia, thus mimicking Evans syndrome, secondary to cluster of differentiation 5‑positive B‑cell lymphoma with massive splenomegaly, in a patient suffering from rheumatoid arthritis for two decades. Treatment with prednisolone, high‑dose dexamethasone, eltrombopag and rituximab for cytopenia were not effective. Chemotherapy with bendamustine subsequently resolved the cytopenia, additionally resulting in a complete remission of lymphoma. Thus, bendamustine may have a role in the management of lymphoma complicated with severe cytopenia.
Publisher
Spandidos Publications
Content Type
Journal Article
Link
ISSN
20499450
EISSN
20499469
Journal Title
MOLECULAR AND CLINICAL ONCOLOGY
Current Journal Title
MOLECULAR AND CLINICAL ONCOLOGY
Volume
7
Issue
5
Start Page
855
End Page
858
Published Date
2017-11
Publisher-DOI
Text Version
Publisher
Rights
Copyright © Spandidos Publications 2017
Citation
Hosoda Yuzuru, Hagino Hiroshi, Hino Norihiko, et al. Efficacy of bendamustine on thrombocytopenia and hemolytic anemia secondary to CD5-positive B-cell lymphoma with massive splenomegaly in a patient with rheumatoid arthritis. MOLECULAR AND CLINICAL ONCOLOGY. 2017. 7(5). 855-858. doi:10.3892/mco.2017.1425
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English
Web of Science Key ut
WOS:000455354600026