ID 8403
File
Authors
Matsunaga, Yohei Hirotsu Bio Science Inc.
Kawano, Tsuyoshi The United Graduate School of Agriculture, Tottori University Researchers DB KAKEN
Keywords
Caenorhabditis elegans
dauer
insulin-like peptide
insulin/IGF-1 signaling
lifespan
Abstract
Insulin and insulin-like peptides (ILPs) are conserved in living organisms to modulate homeostasis by functioning as ligands. For understanding of molecular mechanisms regulated by the ligands, the nematode Caenorhabditis elegans is a good model since: 1) the C. elegans genome size is small with over 40% homology to the human genome, 2) numerous genetic methods are available, and 3) the worms are transparent throughout the life cycle, so that the secretion of peptide hormones can be followed at cellular level in living preparations by GFP-tagged peptides. In this review, we describe the general appearance of the insulin/insulin-like growth factor (IGF)-1 signaling (IIS), and then focus on physiological functions, secretion, and transcriptional regulation of the C. elegans ILPs.
Publisher
AIMS Press
Content Type
Journal Article
ISSN
23779098
Journal Title
AIMS BIOPHYSICS
Volume
5
Issue
4
Start Page
217
End Page
230
Published Date
2018
Publisher-DOI
Text Version
Publisher
Rights
(C) 2018 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
Citation
Matsunaga Yohei, Kawano Tsuyoshi. The C. elegans insulin-like peptides (ILPs). AIMS BIOPHYSICS. 2018. 5(4). 217-230. doi:10.3934/biophy.2018.4.217
Department
Faculty of Agriculture/Graduate School of Agriculture
Language
English
Web of Science Key ut
WOS:000455447600001