ID 8409
File
Authors
Koyama, Satoshi Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine Researchers DB
Fujiwara, Kazunori Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine Researchers DB KAKEN
Nosaka, Kanae Division of Organ Pathology, Department of Microbiology and Pathology, Tottori University Faculty of Medicine Researchers DB
Fukuhara, Takahiro Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine Researchers DB KAKEN
Morisaki, Tsuyoshi Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine
Miyake, Naritomo Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine Researchers DB KAKEN
Kitano, Hiroya Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine / Center for Head and Neck Surgery, Kusatsu General Hospital
Takeuchi, Hiromi Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine Researchers DB KAKEN
Keywords
Autopsy
Paired box 8
PAX8
Squamous cell carcinoma
Thyroid
Abstract
Primary squamous cell carcinoma (SCC) in the thyroid is extremely rare and has been reported in < 1% of all thyroid cancer cases. Primary SCC in the thyroid was thought to be a transitional form derived from adenocarcinomas; therefore, the majority of reported cases have focused on the conjunction with other histological adenocarcinomas. A 73-year-old male presented to our hospital with bilateral vocal fold palsy and an anterior neck mass. Ultrasound sonography revealed a bulky tumor in the thyroid and bilateral cervical lymphadenopathy. We performed fine-needle aspiration cytology from the thyroid tumor, which revealed SCC. Positron emission tomography/computed tomography showed distant metastases in the lungs, mediastinal lymph nodes, and vertebra. We diagnosed the patient as having stage IVC SCC in the thyroid and administered weekly paclitaxel. Four and a half months after treatment initiation, the tumor progression resulted in aspiration pneumonia, which proved fatal. We performed an autopsy in accordance with the patient’s wishes. Pathological findings revealed that all carcinomas in the thyroid, cervical lymph nodes, and lungs were pure SCCs. Immunohistochemical examinations for PAX8, thyroglobulin, and TTF-1 were all negative. Differentiated thyroid carcinomas have 3 major positive markers – PAX8, thyroglobulin, and TTF-1 –, and PAX8 is also sometimes positive for SCC in the thyroid. PAX8 positivity of SCC in the thyroid might, however, be associated with conjunction with other histological adenocarcinomas such as papillary or follicular thyroid carcinoma; therefore, pure SCC in the thyroid might be negative for PAX8.
Publisher
S. Karger AG
Content Type
Journal Article
Link
ISSN
16626575
Journal Title
CASE REPORTS IN ONCOLOGY
Current Journal Title
CASE REPORTS IN ONCOLOGY
Volume
11
Issue
2
Start Page
418
End Page
424
Published Date
2018
Publisher-DOI
Text Version
Publisher
Rights
© 2018 The Author(s) Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
Citation
Koyama Satoshi, Fujiwara Kazunori, Nosaka Kanae, et al. Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case. CASE REPORTS IN ONCOLOGY. 2018. 11(2). 418-424. doi:10.1159/000490410
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English
Web of Science Key ut
WOS:000455063400027