ID 8618
File
Authors
Okura, Tsuyoshi Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Nakamura, Risa Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
Fujioka, Yohei Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Kawamoto-Kitao, Sonoko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
Ito, Yuichi Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
Matsumoto, Kazuhisa Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
Shoji, Kyoko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine
Sumi, Keisuke Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB
Matsuzawa, Kazuhiko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB
Izawa, Shoichiro Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Ueta, Etsuko School of Health Science, Tottori University Faculty of Medicine Researchers DB KAKEN
Kato, Masahiko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Imamura, Takeshi Division of Molecular Pharmacology, Tottori University Faculty of Medicine Researchers DB KAKEN
Taniguchi, Shin-ichi Department of Regional Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Yamamoto, Kazuhiro Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine Researchers DB KAKEN
Abstract
Background: Increased hepatic insulin clearance (HIC) is important in the pathophysiology of type 2 diabetes mellitus (T2DM). The aim of this study is to analyze an effective insulin resistance (IR) index that is minimally affected by HIC. Methods: Our study involved 20 participants with T2DM and 21 healthy participants without diabetes (Non-DM). Participants underwent a meal tolerance test from which plasma glucose, insulin and serum C-peptide immunoreactivity (CPR) were measured, and HOMA-IR and HIC were calculated. Participants then underwent a hyperinsulinemic-euglycemic clamp from which the glucose disposal rate (GDR) was measured. Results: The index CPR-IR = 20/(fasting CPR × fasting plasma glucose) was correlated more strongly with GDR, than was HOMA-IR, and CPR-IR could be used to estimate GDR. In T2DM participants with HIC below the median, HOMA-IR and CPR-IR were equally well correlated with GDR. In T2DM with high HIC, CPR-IR correlated with GDR while HOMA-IR did not. In Non-DM, CPR-IR and HOMA-IR were equally well correlated with GDR regardless of HIC. The mean HIC value in T2DM was significantly higher than that of Non-DM. Conclusions: CPR-IR could be a simple and effective index of insulin resistance for patients with type 2 diabetes that is minimally affected by HIC.
Publisher
Public Library of Science
Content Type
Journal Article
Link
ISSN
19326203
Journal Title
PLOS ONE
Current Journal Title
PLOS ONE
Volume
13
Issue
5
Published Date
2018-05-23
Publisher-DOI
Text Version
Publisher
Rights
© 2018 Okura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation
Okura Tsuyoshi, Nakamura Risa, Fujioka Yohei, et al. CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance-A preliminary research. PLOS ONE. 2018. 13(5). doi:10.1371/journal.pone.0197663
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English
Web of Science Key ut
WOS:000433077000051