ID 8704
File
Authors
Okura, Tsuyoshi Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine Researchers DB KAKEN
Nakamura, Risa Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine
Fujioka, Yohei Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine Researchers DB KAKEN
Kawamoto-Kitao, Sonoko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine
Ito, Yuichi Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine
Matsumoto, Kazuhisa Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine
Shoji, Kyoko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine
Sumi, Keisuke Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine Researchers DB
Matsuzawa, Kazuhiko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine Researchers DB
Izawa, Shoichiro Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine Researchers DB KAKEN
Ueta, Etsuko School of Health Science, Tottori University Faculty of Medicine Researchers DB KAKEN
Kato, Masahiko Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine Researchers DB KAKEN
Imamura, Takeshi Division of Molecular Pharmacology, Tottori University Faculty of Medicine Researchers DB KAKEN
Taniguchi, Shin-ichi Department of Regional Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Yamamoto, Kazuhiro Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine Researchers DB KAKEN
Abstract
Background: Screening for undiagnosed type 2 diabetes mellitus is recommended for Asian Americans with a body mass index ≥23. However, the optimal body mass index cut-off score for predicting the risk of diabetes mellitus in Japanese people is not well known. The aim of this study was to determine the best body mass index cut-off score for predicting insulin resistance and diabetes mellitus in the Japanese population. Methods: This study had two parts, a clinical investigation and a retrospective observational investigation. In the clinical part of the study, 58 participants (26 with type 2 diabetes mellitus and 32 non-diabetics) underwent a hyperinsulinemic-euglycemic clamp from which their glucose disposal rate was measured. For the retrospective part of the study, medical check-up data from 88,305 people in the Tottori Prefecture were analyzed for clinical evidence of diabetes mellitus. The optimal BMI cut-off scores for prediction of insulin resistance and diabetes mellitus were determined. Results: In the clamp study, the optimal body mass index cut-off score to predict insulin resistance in non-diabetic patients was 22.7. All participants with type 2 diabetes mellitus were insulin resistant, and the optimal body mass index cut-off score for prediction of severe insulin resistance was 26.2. When the data from the type 2 diabetic and the non-diabetic participants were combined, the optimal body mass index cut-off score for prediction of insulin resistance was 23.5. Analysis of 88,305 medical check-up records yielded an optimal body mass index cut-off score for prediction of diabetes mellitus of 23.6. Conclusions: These results suggest that having a body mass index ≥23 is a risk factor for insulin resistance and diabetes mellitus in the Japanese population.
Publisher
Public Library of Science
Content Type
Journal Article
Link
ISSN
19326203
Journal Title
PLOS ONE
Current Journal Title
PLOS ONE
Volume
13
Issue
7
Published Date
2018-07-20
Publisher-DOI
Text Version
Publisher
Rights
Copyright: © 2018 Okura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation
Okura Tsuyoshi, Nakamura Risa, Fujioka Yohei, et al. Body mass index >= 23 is a risk factor for insulin resistance and diabetes in Japanese people: A brief report. PLOS ONE. 2018. 13(7). doi:10.1371/journal.pone.0201052
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English
Web of Science Key ut
WOS:000439396900036