ID | 9080 |
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Authors |
Murata, Akihiko
Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University
Researchers DB
KAKEN
Hikosaka, Mari
Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine
Yoshino, Miya
Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University
Researchers DB
Zhou, Lan
Department of Pathology, Case Western Reserve University
Hayashi, Shin-ichi
Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University
Researchers DB
KAKEN
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Keywords | Delta-like
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Abstract | Kit/CD117 plays a crucial role in the cell–cell and cell–matrix adhesion of mammalian mast cells (MCs); however, it is unclear whether other adhesion molecule(s) perform important roles in the adhesion of MCs. In the present study, we show a novel Kit-independent adhesion mechanism of mouse cultured MCs mediated by Notch family members. On stromal cells transduced with each Notch ligand gene, Kit and its signaling become dispensable for the entire adhesion process of MCs from tethering to spreading. The Notch-mediated spreading of adherent MCs involves the activation of signaling via phosphatidylinositol 3-kinases and mitogen-activated protein kinases, similar to Kit-mediated spreading. Despite the activation of the same signaling pathways, while Kit supports the adhesion and survival of MCs, Notch only supports adhesion. Thus, Notch family members are specialized adhesion molecules for MCs that effectively replace the adhesion function of Kit in order to support the interaction of MCs with the surrounding cellular microenvironments.
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Publisher | Oxford University Press
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Content Type |
Journal Article
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Link | |
ISSN | 09538178
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EISSN | 14602377
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Journal Title | INTERNATIONAL IMMUNOLOGY
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Current Journal Title |
INTERNATIONAL IMMUNOLOGY
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Volume | 31
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Issue | 2
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Start Page | 69
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End Page | 79
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Published Date | 2019-02
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Text Version |
Author
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Rights | This is a pre-copyedited, author-produced version of an article accepted for publication in INTERNATIONAL IMMUNOLOGY following peer review. The version of record Akihiko Murata, Mari Hikosaka, Miya Yoshino, Lan Zhou, Shin-Ichi Hayashi, Kit-independent mast cell adhesion mediated by Notch, International Immunology, Volume 31, Issue 2, February 2019, Pages 69–79, https://doi.org/10.1093/intimm/dxy067 is available online at: https://doi.org/10.1093/intimm/dxy067
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Citation | Murata Akihiko, Hikosaka Mari, Yoshino Miya, et al. Kit-independent mast cell adhesion mediated by Notch. INTERNATIONAL IMMUNOLOGY. 2019. 31(2). 69-79. doi:10.1093/intimm/dxy067
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Department |
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
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Language |
English
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Web of Science Key ut | WOS:000461515600002
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