ID 913
File
Authors
Keywords
acute myocardial infarction
heart failure
persistent pulmonary hypertension of the newborn
transient myocardial ischemia of the newborn infant
Abstract
We compared the serum concentrations of myosin light chain I (MLC-I) and left ventricular shortening fraction (LVSF) measured by echocardiography of 13 normal neonates with those of 38 neonates with fetal distress, neonatal asphyxia, or cardiovascular/respiratory diseases not associated with structural abnormalities. The diseased group included 9 neonates with elevated MLC-I concentrations and 18 with low LVSF. Elevated MLC-I concentrations were frequently noted in neonates with transient myocardial ischemia and persistent pulmonary hypertension of the newborn, suggesting a high specificity of MLC-I elevation in these diseases. Although echocardiographically determined LVSF identifies the affected sections of the myocardium, it did not allow rating of the severity of the disorder. There was no correlation between MLC-I and LVSF probably due to therapeutic interventions and pulmonary hypertension. Our results suggest that MLC-I is a useful marker of neonatal myocardial diseases.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
42
Issue
1
Start Page
69
End Page
78
Published Date
1999-03
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 1999, 42(1), 69-78
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English