ID 939
File
Authors
Keywords
cholesterol
infertility
sperm
temperature
testis
Abstract
The effect of hypercholesterolaemia on testicular endocrine and exocrine function was evaluated. Furthermore, the influence of hypercholesterolaemia on sperm quality, quantity, and fertilizing potential was appreciated. Eight mature rabbits (group A) were fed chow containing 3% cholesterol for 12 weeks. An additional six rabbits (group B) were fed normal chow for the same period. At the end of the experimental period hormonal profiles and sperm parameters were evaluated. In addition, the sperm reproductive potential was assessed by in vitro fertilization (IVF) procedures. Peripheral serum responses to testicular stimulation with human chorionic gonadotropin, epididymal sperm content and motility, and IVF outcome were significantly lower in group A than in group B. In contrast, serum cholesterol levels were significantly higher in group A. It appears that hypercholesterolaemia has a detrimental effect on Leydig cell function, spermatogenesis, the epididymal sperm maturation process, and the overall sperm fertilizing capacity.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
41
Issue
1
Start Page
23
End Page
29
Published Date
1998-03
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 1998, 41(1), 23-29
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English