File
Authors
Inoue, Masashi
Keywords
colorectal cancer
DNA topoisomerase I
immunohistochemistry
prognosis
Abstract
Topoisomerase I (Topo I) is known as a target for chemotherapy in advanced or recurrent colorectal cancer. In order to prolong the survival of patients with colorectal cancer or to prevent ineffective chemotherapy, we evaluated clinicopathological characteristics of Topo I protein in colorectal cancer. Also, we estimated whether Topo I protein expression of primary tumors could be a parameter for chemosensitivity of Topo I inhibitor in patients with cancer recurrence. Immunohistochemical detection of Topo I protein was performed in 104 surgically obtained specimens. Topo I protein was detected in 45 of 104 patients (43.2%). Topo I protein expression closely correlated with tumor progression, histpathological differentiation and poor prognosis of patients. Sixteen patients with recurrent cancer had been treated with Topo I inhibitor. Topo I inhibitor significantly prolonged the survival of 12 patients who had Topo I-positive primary tumors. Topo I protein expression in colorectal cancer may be a biological marker for chemosensitivity of tumors against Topo I inhibitors.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
50
Issue
4
Start Page
81
End Page
87
Published Date
2007-12
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 2007, 50(4), 81-87
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English