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Authors
Hara, Sayuri Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine
Nagata, Keiko Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Nakayama, Yuji Division of Radioisotope Science, Research Initiative Center, Organization for Research Initiative and Promotion Researchers DB KAKEN
Higaki, Katsumi Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University Researchers DB KAKEN
Matsushita, Michiko Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine Researchers DB KAKEN
Kuwamoto, Satoshi Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Kato, Masako Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Hayashi, Kazuhiko Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Keywords
anti-gp350/220 antibody (72A1)
Epstein-Barr virus, estradiol
Graves’ disease
reactivation
Abstract
Graves’ disease occurs predominantly in women. Epstein-Barr virus (EBV) mainly persists in human B lymphocytes, and its reactivation stimulates antibody production. We previously suggested that the EBV reactivation-induced production of TRAb and IgM at 100 nM estradiol (pregnant level) was lower than that at 0 nM estradiol and that class switch recombination may be increased by estradiol. In this study, we examined the effect of estradiol on EBV reactivation. We identified the expression of EBV-glycoprotein 350/220 (gp350/220) in the late phase of reactivation and plasma cell differentiation of EBV-infected cells using 72A1 antibody and CD138 antibody, respectively. We found the mean ratio of gp 350/220(+) CD138(+) cells at 100 nM estradiol was higher than that at 0 nM estradiol. These results suggested that EBV-infected cells could survive with keeping the ability of antibody production in 100 nM estradiol, which is consistent with the improvement of Graves’ disease during maternity and exacerbation postpartum.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN・ISBN
05135710
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
62
Issue
2
Start Page
240
End Page
243
Published Date
2019-06-20
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Sayuri Hara, Keiko Nagata, Yuji Nakayama, Katsumi Higaki, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Kazuhiko Hayashi, High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease Patients and Healthy Controls, Yonago Acta Medica, 2019, Volume 62, Issue 2, Pages 240-243
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English