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Authors
Kimura, Yusuke Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB
Honda, Masashi Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Morizane, Shuichi Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Hikita, Katsuya Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Isoyama, Tadahiro Torrori Prefectual Central Hospital
Ono, Koji Japanese Red Cross Tottori Hospital
Koumi, Tsutomu Japanese Red Cross Tottori Hospital
Takahashi, Chihiro Yonago Medical Center
Takenaka, Atsushi Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine Researchers DB KAKEN
Keywords
bacilli calmette-guerin therapy
bladder cancer
second transurethral resection
Abstract
Background: To evaluate the efficacy of Bacilli Calmette-Guerin (BCG) induction instillation therapy after second transurethral resection (TUR) in stage Ta T1 high-grade bladder cancer.
Methods: We performed a retrospective analysis of 49 consecutive new onset Ta T1 high-grade bladder cancer patients treated with second TUR at our affiliated institutions. Residual cancer rate, intravesical recurrence-free survival (RFS), and risk factors related to RFS were evaluated by univariate and multivariate Cox proportional hazard model analyses.
Results: Thirty-one patients received BCG therapy after the second TUR (BCG group), and 18 patients were treated with second TUR alone (no BCG group). There were statistically significant differences in the RFS rates between the two groups, (P = 0.037). BCG therapy was the only factor predictive of intravesical recurrence after second TUR in both univariate and multivariate analyses. After the second TUR, BCG therapy significantly decreased intravesical recurrence in the patients with residual tumors (P = 0.014). However, there was no significant difference in intravesical recurrence in the patients with no residual tumors between the two groups (P = 0.359).
Conclusion: BCG therapy after second TUR significantly decreased intravesical recurrence of residual tumors found at the second TUR.
Publisher
Tottori University Medical Press
Content Type
Journal Article
Link
ISSN・ISBN
05135710
NCID
AA00892882
Journal Title
Yonago Acta Medica
Current Journal Title
Yonago Acta Medica
Volume
62
Issue
2
Start Page
191
End Page
197
Published Date
2019-06-20
Publisher-DOI
Text Version
Publisher
Rights
注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation
Yusuke Kimura, Masashi Honda, Shuichi Morizane, Katsuya Hikita, Tadahiro Isoyama, Koji Ono, Tsutomu Koumi, Chihiro Takahashi, Atsushi Takenaka, Effect of Intravesical Bacilli Calmette-Guerin Therapy After Second Transurethral Resection in Stage Ta T1 High-Grade Bladder Cancer, Yonago Acta Medica, 2019, Volume 62, Issue 2, Pages 191-197
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English