File
Authors
Keywords
bisphosphonate pamidronate
humoral hypercalcemia of malignancy
parathyroid hormone-related protein
Abstract
We present here successful treatment with bisphosphonate pamidronate of a 54-year-old patient with advanced ovarian cancer and humoral hypercalcemia of malignancy, followed by cytoreductive surgery and postoperative chemotherapy. Concentration of serum calcium increased to 16.8 mg/dL and parathyroid hormone-related protein (PTHrP)-intact was remarkably elevated. Interestingly, the 1,25-dihydroxyvitamin D (1,25-DHD) was high in this case. Treatment with bisphosphonate pamidronate was effective for the improvement of hypercalcemia so that she could undergo optimal surgery followed by postoperative chemotherapy. The histochemical examination of PTHrP using anti-human monoclonal antibody showed positive staining in the cancer cells of the ovary.
Publisher
Tottori University Faculty of Medicine
Content Type
Journal Article
ISSN・ISBN
1346-8049
NCID
AA00892882
Journal Title
Yonago Acta medica
Current Journal Title
Yonago Acta medica
Volume
43
Issue
2
Start Page
81
End Page
86
Published Date
2000-07
Text Version
Publisher
Rights
Yonago Acta medica 編集委員会
Citation
Yonago Acta medica. 2000, 43(2), 81-86
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English