File
Title Transcription
コウジョウセン シュヨウ ソシキ ニ オケル テンシャ ヨクセイ インシ PLZF ノ ハツゲン パターン ニ ツイテ ノ ケントウ
Title Alternative
Transcriptional repressor PLZF is differentially expressed in thyroid neoplasm,reflecting the impairment of follicular formation
Authors
Keywords
PLZF
thyroid neoplasm
tumorigenesis
folliculogenesis
Abstract
PLZF (Promyelocytic Leukemia Zn Finger) is a transcriptional repressor which is originally isolated from a patient with promyelocytic leukemia. Moreover, PLZF affects the key element of cell cycle progression such as cyclin A. So far, the functional role of PLZF in thyroid cells remains unclear. In this study, we analyzed the expression profile of PLZF in thyroid neoplasms. We estimated PLZF expression in normal thyroid (n=6), multinodular goiter (n=4), follicular adenoma (n=3), follicular carcinoma (n=1), papillary carcinoma (n=18) and anaplastic carcinoma (n=3). PLZF expression was estimated by immunohistochemical staining and western blotting. In all of papillary carcinoma, PLZF is expressed in cytosol with high intensity. In contrast, in normal thyroid, follicular adenoma and follicular carcinoma, P LZF is localized in nucleus. We speculate that the intracellular translocation of PLZF reflects the differentiation between benign and malignancy. Although follicular carcinoma is malignant tissue, its PLZF expression pattern was same as benign thyroid tissues. Then differentiation of PLZF expression in follicular carcinoma from papillary carcinoma and anaplastic carcinoma is due to retaining follicular structure. We presume that PLZF expression in nucleus could be related to the maintenance of follicular structure.
Publisher
米子医学会
Content Type
Departmental Bulletin Paper
ISSN
0044-0558
NCID
AN00247383
Journal Title
米子医学雑誌
Current Journal Title
米子医学雑誌
Volume
63
Issue
1
Start Page
15
End Page
21
Published Date
2012-01-31
Text Version
Publisher
Citation
米子医学雑誌. 2012, 63(1), 15-21
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
Japanese