File yam63(3)_228.pdf/
Authors Yamaga, Kensaku/ Kuwamoto, Satoshi/ Mukunoki, Daichi/ Osaki, Mari/ Nagashima, Hideki/
Keywords denosumab/ elderly/ giant cell tumor of bone/ histone 3.3 G34W/ unresectable/
Abstract We report a case of GCTB in an 84-year-old Japanese man who had a tumor in his left iliac bone and was treated safely with denosumab. The patient noticed a painful mass, with gradual enlargement, in his left low back next to the iliac region. Magnetic resonance imaging revealed that the tumor measured 94 × 66 × 90 mm and was located in the left iliac bone. Histologically, the tumor was composed of proliferative oval-shaped mononuclear cells, admixed with large number of osteoclast-like giant cells. Immunohistochemically, a strong positivity for histone 3.3 G34W mutant protein was observed in the nuclei of the mononuclear cells, confirming the diagnosis of GCTB. Because it was considered as unresectable tumor, the patient was treated with denosumab without any side effects.
Publisher Tottori University Medical Press
Content Type Journal Article
Link http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html
ISSN 13468049
NCID AA00892882
Journal Title Yonago Acta Medica
Current Journal Title Yonago Acta Medica
Volume 63
Issue 3
Start Page 228
End Page 233
Published Date 2020-08-20
Publisher-DOI 10.33160/yam.2020.08.013
Text Version Publisher
Rights 注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.
Citation Kensaku Yamaga, Satoshi Kuwamoto, Daichi Mukunoki et al. Successful Treatment with Denosumab of a Giant Cell Tumor of Bone in the Iliac Bone of an 84-Year-Old Man. Yonago Acta Medica. 2020. 63(3). 228-233. doi: 10.33160/yam.2020.08.013.
Department Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language English
Authors Matsumoto, Hiromi/ Okuno, Makoto/ Nakamura, Tatsuhiko/ Yamamoto, Kichizo/ Osaki, Mari/ Hagino, Hiroshi/
Content Type Journal Article
Journal Title Yonago Acta medica
Current Journal Title Yonago Acta medica
Volume 57
Issue 4
Published Date 2014-12
Authors Yamaga, Kensaku/ Minamizaki, Takeshi/ Osaki, Mari/ Shomori, Kohei/ Ishiguro, Naoko/ Yoshida, Haruhiko/ Ito, Hisao/
Content Type Journal Article
Journal Title Yonago Acta medica
Current Journal Title Yonago Acta medica
Volume 51
Issue 3
Published Date 2008-09
Authors Osaki, Mari/ Osaki, Mitsuhiko/ Kodani, Isamu/ Adachi, Hironobu/ Shibata, Itoji/ Ito, Hisao/
Content Type Journal Article
Journal Title Yonago Acta medica
Current Journal Title Yonago Acta medica
Volume 45
Issue 4
Published Date 2002-12