File
Authors
Ehara, Yuko Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine,Tottori University
Yamamoto, Osamu Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University Researchers DB KAKEN
Kosaki, Kenjiro Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University
Yoshida, Yuichi Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University Researchers DB KAKEN
Keywords
cutaneous neurofibroma
distribution
neurofibromatosis 1
NF1
predilection body site
Abstract
Neurofibromatosis 1 (NF1) is characterized by cutaneous, neurological and osseous manifestations. Most NF1 patients develop cutaneous neurofibromas. However, time‐dependent change with aging and the predilection site of cutaneous neurofibromas remain unclear. To clarify the natural course and characteristics of cutaneous neurofibromas, a retrospective study was conducted for 57 NF1 patients who were treated at the Department of Dermatology of Tottori University Hospital between January 2007 and April 2016. For each patient, we investigated the time‐dependent changes and the numbers of cutaneous neurofibromas in four body surface regions. There was a positive correlation between age and number of cutaneous neurofibromas (r = 0.75, P < 0.001). Cutaneous neurofibromas were located on the trunk (60.2%), lower limbs (16.1%), upper limbs (14.4%), and head and neck (9.2%). There was no significant relationship between each body type (e.g. obese or thin) and cutaneous neurofibromas. With respect to the year‐to‐year percentage change in cutaneous neurofibromas, the average annual rate of increase was 0.21 (range, −0.71 to 1.2). The number of cutaneous neurofibromas had increased in approximately 61% of the patients 1 year later. Our data will enable physicians to estimate the overall state of cutaneous neurofibromas in NF1 and will be useful for handling cutaneous manifestations before they become a serious condition.
Publisher
WILEY
Content Type
Journal Article
Link
ISSN
03852407
EISSN
13468138
NCID
AA00696658
Journal Title
JOURNAL OF DERMATOLOGY
Current Journal Title
JOURNAL OF DERMATOLOGY
Volume
45
Issue
1
Start Page
53
End Page
57
Published Date
2018
Publisher-DOI
Text Version
Author
Rights
(C) 2017 Japanese Dermatological Association
Citation
Ehara Yuko, Yamamoto Osamu, Kosaki Kenjiro, et al. Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1. JOURNAL OF DERMATOLOGY. 2018. 45(1). 53-57. doi:10.1111/1346-8138.14025
Department
Faculty of Medicine/Graduate School of Medical Sciences/University Hospital
Language
English
Web of Science Key ut
WOS:000419601100020